• PARK2Parkinson disease (autosomal recessive, juvenile) 2, parkin

  • Detail information

    Gene Symbol PARK2
    Full name Parkinson disease (autosomal recessive, juvenile) 2, parkin
    Synonym AR-JP, LPRS2, PDJ, PRKN
    Genome position chromosome: 6; Location: 6q25.2-q27
    163148802 .. 161769670 (strand : -)
    Links EntrezGene
    UCSC
    OMIM

    The GRCh37/hg19 sequence assembly is used for the human genomic reference sequence.

  • Sequence information

    Exon : Intron 100:1 50:1 10:1 3:1 1:1   Age onset & duration hide show

    expanded image




    a.a. : NP_004553.1

    mRNA : NM_004562.1

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  • Mutation & Clinical information

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  • Multiple alignments

    Multiple alignments of all patients' sequences   (Registration is needed to see this information, because unpublished data is contained.)

    Multiple alignments of orthologous sequences

  • 3D structure

    show 1iyf.pdb

  • Structure information

    Exon Start AA End AA Structure
    1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11 1 465 Chain
    1, 2 1 76 Domain
    5, 6, 7 238 293 Zinc finger region
    8, 9 313 377 Zinc finger region
    10, 11 418 449 Zinc finger region
    4, 5 204 238 Region of interest
    6, 7 257 293 Region of interest
    1, 2, 3, 4 1 191 Splice variant
    1, 2 1 79 Splice variant
    4, 5 179 206 Splice variant
    7 290 290 Splice variant
    7 291 297 Splice variant
    7, 8, 9, 10, 11 298 465 Splice variant
    9 362 368 Splice variant
    9, 10, 11 369 465 Splice variant
    1 15 15 Sequence variant
    1 33 33 Sequence variant
    1 37 37 Sequence variant
    1 42 42 Sequence variant
    1 46 46 Sequence variant
    2 82 82 Sequence variant
    2 92 92 Sequence variant
    2 100 100 Sequence variant
    3 161 161 Sequence variant
    3 167 167 Sequence variant
    4 192 192 Sequence variant
    5 211 211 Sequence variant
    5 211 211 Sequence variant
    5 212 212 Sequence variant
    5 240 240 Sequence variant
    5 240 240 Sequence variant
    6 253 253 Sequence variant
    6 256 256 Sequence variant
    6 271 271 Sequence variant
    6 275 275 Sequence variant
    6 280 280 Sequence variant
    6 284 284 Sequence variant
    6 289 289 Sequence variant
    8 328 328 Sequence variant
    8 334 334 Sequence variant
    8 339 339 Sequence variant
    8 351 351 Sequence variant
    9 366 366 Sequence variant
    9 380 380 Sequence variant
    10 394 394 Sequence variant
    10 415 415 Sequence variant
    11 430 430 Sequence variant
    11 431 431 Sequence variant
    11 437 437 Sequence variant
    11 441 441 Sequence variant
    8 332 332 Mutagenesis site
    8 337 337 Mutagenesis site
    9 365 365 Mutagenesis site
    10 418 418 Mutagenesis site
    10 421 421 Mutagenesis site
    11 431 431 Mutagenesis site
    5 223 223 Sequence conflict
    6, 7 289 290 Sequence conflict
    8 339 339 Sequence conflict
    1 2 7 Strand
    1 8 10 Turn
    1 11 17 Strand
    1 19 21 Strand
    1 23 33 Helix
    1 38 45 Strand
    1 48 50 Strand
    1 52 55 Turn
    2 57 60 Helix
    2 63 70 Strand
    8 318 320 Strand
    8 334 336 Strand
    8 354 356 Strand
    9 366 369 Turn
    9 377 379 Strand

  • Overview of mutations

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