• LRRK2leucine-rich repeat kinase 2
  • Detail information

    Gene Symbol LRRK2
    Full name leucine-rich repeat kinase 2
    Synonym AURA17, PARK8, RIPK7, ROCO2
    Genome position chromosome: 12; Location: 12q12
    40618813 .. 40763086 (strand : +)
    Links EntrezGene
    UCSC
    OMIM

    The GRCh37/hg19 sequence assembly is used for the human genomic reference sequence.
  • Sequence information

    Exon : Intron 100:1 50:1 10:1 3:1 1:1   Age onset & duration hide show

    expanded image




    a.a. : NP_940980.2

    mRNA : NM_198578.2
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  • Mutation & Clinical information

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  • Multiple alignments

    Multiple alignments of all patients' sequences   (Registration is needed to see this information, because unpublished data is contained.)

    Multiple alignments of orthologous sequences
  • 3D structure

    3D Structure data is not found.
  • Structure information

    Exon Start AA End AA Structure
    1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, 50, 51 1 2527 Chain
    6, 7 226 249 Repeat
    19 791 815 Repeat
    23 981 1004 Repeat
    23, 24 1010 1033 Repeat
    24 1035 1057 Repeat
    24 1059 1081 Repeat
    24 1082 1105 Repeat
    24, 25 1107 1127 Repeat
    25 1128 1151 Repeat
    26 1172 1194 Repeat
    26, 27 1195 1219 Repeat
    27 1221 1243 Repeat
    27, 28 1244 1268 Repeat
    28 1270 1291 Repeat
    29, 30, 31 1335 1455 Domain
    32 1556 1579 Repeat
    38, 39 1861 1887 Repeat
    38, 39, 40, 41, 42, 43, 44 1879 2138 Domain
    29 1341 1348 Nucleotide phosphate-binding region
    38, 39 1885 1893 Nucleotide phosphate-binding region
    43 2098 2121 Nucleotide phosphate-binding region
    47 2295 2298 Nucleotide phosphate-binding region
    8, 9 319 348 Coiled-coil region
    18 728 731 Compositionally biased region
    41 1994 1994 Active site
    39 1906 1906 Binding site
    1 50 50 Sequence variant
    4 119 119 Sequence variant
    11 419 419 Sequence variant
    14 551 551 Sequence variant
    18 723 723 Sequence variant
    19 755 755 Sequence variant
    19 793 793 Sequence variant
    21 930 930 Sequence variant
    22 944 944 Sequence variant
    24 1067 1067 Sequence variant
    24 1096 1096 Sequence variant
    25 1122 1122 Sequence variant
    27 1228 1228 Sequence variant
    28 1262 1262 Sequence variant
    29 1371 1371 Sequence variant
    30 1398 1398 Sequence variant
    31 1441 1441 Sequence variant
    31 1441 1441 Sequence variant
    31 1441 1441 Sequence variant
    32 1514 1514 Sequence variant
    32 1542 1542 Sequence variant
    33 1598 1598 Sequence variant
    34 1628 1628 Sequence variant
    34 1646 1646 Sequence variant
    34 1647 1647 Sequence variant
    35 1699 1699 Sequence variant
    38 1869 1869 Sequence variant
    40 1941 1941 Sequence variant
    41 2012 2012 Sequence variant
    41 2019 2019 Sequence variant
    41 2020 2020 Sequence variant
    42 2081 2081 Sequence variant
    43 2119 2119 Sequence variant
    46 2261 2261 Sequence variant
    48 2356 2356 Sequence variant
    48 2385 2385 Sequence variant
    49 2397 2397 Sequence variant
    28 1260 1271 Sequence conflict
  • Overview of mutations

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